万年蒿提取物对小鼠肝损伤的保护作用

Protective Effects of Extracts of Artemisia sacrorum Ledeb.on Acute Hepatic Injury in Mice

目的探讨万年蒿超临界萃取物和水提液对小鼠肝脏损伤的保护作用。方法分别以万年蒿超临界萃取物和水提液灌胃小鼠,并以CCl4制成小鼠急性肝脏损伤模型,测定小鼠血清中门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)含量,观察万年蒿不同提取物对肝脏损伤的保护作用。结果和模型组相比,万年蒿水提液高剂量组和超临界萃取物高剂量组能够明显降低小鼠的AST,ALT含量(P<0.05或P<0.001)。结论万年蒿提取物具有较好的保肝作用。

Objective To study the protective effects of supercritical fluid extraction （SFE） extracts and water extracts of Artemisia sacrorum Ledeb. on acute hepatic injury in mice. Methods The mice were peffused with water extracts and SFE extracts respectively. The mouse model of acute hepatic injury were induced by CCl4 and the serum levels of ALT and AST of the mice were measured. Results The high - dose groups of water extracts and of SFE extracts greatly decreased AST and ALT levels in serum compared to model group（ P 〈 0.05 or P 〈 0. 001 ）. Conclusion The extracts of Artemisia sacrorum Ledeb. have protective effects against hepatic injury.