新复方蓖麻餐对中期妊娠大鼠血内皮素及血栓素、前列环素代谢产物的影响

The Effect on the Indexes Concerning TXB2 of Second Trimester Pregnancy Rat with New Compound Castor Meal

目的通过新复方蓖麻餐对中期妊娠大鼠内皮素、前列腺素等因子的影响,阐明其引产作用机制。方法给与中期妊娠大鼠不同剂量新复方蓖麻餐3 d,静脉采血进行内皮素、前列腺素等指标的测定,观察给药后对上述指标的影响,同时观察给药后对受孕率及大鼠一般情况的影响。结果新复方蓖麻餐对中期妊娠大鼠血栓素代谢产物(TXB2),前列环素代谢产物(6-Keto-PGF1α)具有明显影响(P<0.01),但对内皮素和催产素影响不明显(P>0.05)。结论新复方蓖麻餐对中期妊娠大鼠的引产作用,可能与其对血栓素代谢产物(TXB2)、前列环素代谢产物(6-Keto-PGF1α)的影响有关。

Objective According to observing the indexes concerning ET. PGs of second trimester pregnancy rat with New Compound Castor Meal to illuminate the mechanism of second trimester pregnancy induced labor. Methods To feed second trimester pregnancy rats with different close New Compound Castor Meal 3 days, then collect vein blood to observe the change of ET. PGs rat pregnancy rate and general activities. Results For the changes of TXB2 and 6 -Keto -PGF1α , New Compound Castor Meal have obviously influence on Second Trimester Pregnancy Rat （P 〈0.01 ）, but the effect is unconspicuous to the indexes of ET and （ P 〉 0.05 ）. Conclusion The main mechanism of second trimester pregnancy rat induced Labor with New Compound Castor Meal is related to the change of TXB2 and 6 - Keto - PGF1 α.