乳杆菌活菌制剂用于外阴阴道假丝酵母菌病疗效分析

Analysis of probiotic lactobacillus′s effect on vulvovaginal candidiasis

目的探讨乳杆菌活菌制剂联合克霉唑治疗外阴阴道假丝酵母菌病的效果。方法将169例外阴阴道假丝酵母菌病的妇女随机分为2组,分别给予2种治疗方法。A组(85例),乳杆菌活菌胶囊(定君生)与克霉唑联合用药:每日晨1粒定君生胶囊塞入阴道,且每日晚1片克霉唑栓塞入阴道,连续用药10 d;B组(84例),单用克霉唑,每晚1片克霉唑栓塞入阴道,连续用药10 d。2组患者经治疗的5 d、10 d、停药后7 d及月经来潮后复检,临床进行综合评价并行比较。结果A组治疗第5天的痊愈率和显效率比B组明显增高,差异有显著性(P<0.01);A组治疗第5天的无效率比B组明显降低,差异有显著性(P<0.01)。治疗第10天2组间的痊愈率、显效率、有效率差异无显著性。而停药后7 d、月经来潮后的总有效率A组比B组明显增高,复发率A组比B组明显下降,差异有显著性(P<0.05)。结论治疗外阴阴道假丝酵母菌病时,乳杆菌活菌制剂联合克霉唑较单用克霉唑能更快起效,并且有效减少停药后7 d及月经来潮后的复发率。

Objective To investigate the effect of lactobacillus with clotrimazole in the treatment of vulvovaginal candidiasis. Methods 169 patients were divided into 2 groups. Group A （85 cases） was treated with probiotic lactobacillus and clotrimazole pessary for 10 days. Group B（84 cases） was treated with clotrimazole pessary for 10 days. An examination was made after 5 days of treatment, 10 days of treatment, 7 days after the treatment, after the next menstruation. Resuits Cure rate, significant efficiency rate, mild efficiency rate of group A were higher than group B in the 5 days of treatment（P 〈 0.01 ）. There was no significant difference in cure rate between 2 groups in the 10th day of treatment. The total efficiency rate of group A after the 7th day of treatment and after the next menstruation was higher than group B. The recurrent rate of group A was lower than group B（ P 〈 0.05 ）. Conclusion Lactobacillus with clotrimazole can improve the treatment of vulvovaginal candidiasis, and can reduce the recurrent rate in the 7 days after the treatment and after the next menstruation.