改制前后我院G^-杆菌下呼吸道感染的细菌学分类及抗生素耐药性变化

The change in bacterial varieties and drug resistance of Gram-negative bacillic in lower respiratory tract infection after structural reform of our hospital

目的调查改制前后哈尔滨医科大学附属第四医院G-杆菌下呼吸道感染的细菌学分类及抗生素耐药性变化。方法利用复星公司FOUTUNE. IMS细菌鉴定药敏分析系统进行细菌鉴定药敏分析,室内质控菌株选用ATCC25922、ATCC25923、ATCC27853。结果改制后:(1)葡萄球菌感染率降低,而真菌感染率增高。(2)克雷伯菌属比率增高,而肠杆菌属、不动杆菌属比率降低。(3)对头孢哌酮、头孢曲松、头孢噻肟、庆大霉素、柰替米星、妥布霉素、阿米卡星、环丙沙星、诺氟沙星、氧氟沙星、氯霉素、呋喃妥因、四环素、复合磺胺、氨曲南的总耐药率增高。结论合理使用抗生素,注意抗生素和消毒剂耐药的监控是降低细菌耐药性的方法。

Objective To investigate the change of bacterium varieties and antibiotic resistance in lower respiratory tract infection after our hospital reorganized into the forth affiliated hospital of Harbin Medical University. Methods Identification of bacteria and analysis of drug sensitivity was carried out by FOUTUNE. IMS bacteria identification and drug sensitivity analysis system which was produced by Fu Xin Company. ATCC 25922, ATCC 25923, ATCC 27853 were chosen as indoor quality control strains. Results After reorganization： （ 1 ） the infection rate of staphylococci was significantly increased while fungi was significantly decreased. （2）the proportion of klebsiella was increased while enterobacter and acinetobacter were decreased. （ 3 ） the total incidence of drug resistance to cefoporazone, ceftriaxone, cefotaxim, gentamicin, netilmicin, tenebrimycin, amikacin, ciprofloxacin, norfloxacin, ofloxacin, chloromycetin, furadantin, tetracycline, compound sulfanilamide and aztreonam was increased. Conclusions Using antibiotics reasonablely and pay more attention to monitoring antibiotic resistance and antiseptic resistance are effective methods to decrease the incidence of drug resistance.