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端粒生物学与肿瘤治疗

Telomere Biology and Cancer Therapy
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摘要 端粒的生物学功能主要是保护染色体末端,避免核酸酶对染色体末端的降解,防止染色体之间发生融合和重排。大多数人类肿瘤细胞通常通过端粒酶活性的重新激活来延长端粒,从而稳定染色体端粒DNA的长度。端粒酶是由端粒酶逆转录酶和端粒酶RNA模板组成的具有特殊逆转录活性的核糖核蛋白复合物。抑制端粒酶阳性细胞中的端粒酶活性会导致细胞凋亡或衰老。目前有多种以端粒和端粒酶为靶点来进行肿瘤治疗的策略。 The main biological function of telomere is protecting the end of chromosome from end-to-end fusion, recombination and degradation. In most malignant cells, the maintenance of telomeres is achieved by upregulating the expression of the telomerase enzyme. Telomerase is a specialized reverse transcriptase that is minimally composed of a protein catalytic subunit and a RNA component, The inhibition of the telomerase activity in hTERT-positive cells leads to senescencelike growth arrest and apoptosis. Therefore, telomeres and telomerase have been proposed as preferential targets for anticancer drug development.
作者 孙士鹏 黄君健
机构地区 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2007年第4期670-673,共4页 Letters in Biotechnology
关键词 端粒 端粒酶 肿瘤治疗 telomere telomerase cancer therapy
分类号 Q26 [生物学—细胞生物学]
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参考文献39

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二级参考文献16

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生物技术通讯
2007年 第4期

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