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获得性免疫缺陷综合征抗病毒治疗 被引量:1

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摘要 获得性免疫缺陷综合征(AIDS)抗病毒治疗经历了近20年的发展,治疗思路从抑制人类免疫缺陷病毒(HIV)的逆转录酶到抑制蛋白酶,目前又开发出抑制宿主细胞的病毒受体、与受体结合的病毒包膜蛋白以及病毒整合到宿主细胞核酸中所需要的整合酶药物。同时,也在不断进行AIDS的基因治疗和HIV疫苗的研究,目标是找到彻底清除HIV方法。
出处 《内科理论与实践》 2007年第4期228-231,共4页 Journal of Internal Medicine Concepts & Practice
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  • 1Goebel F, Yakovlev A, Pozniak AL,et al.Short-term antivial activity of TMC278-a novel NNRTI-in treatment-naive HIV-1-infected subjects[J]. AIDS, 2006, 20(13): 1721-1726.
  • 2Grinsztejn B, Nguyen BY, Katlama C,et al.Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatmentexperienced patients with multidrugresistant virus:a phase Ⅱ randomised controlled trial[J]. Lancet, 2007, 369:1261-1269.
  • 3Lataillade M, Kozal MJ. The hunt for HIV-1 integrase inhibitors[J]. AIDS Patient Care STDS, 2006, 20: 489-501.
  • 4Markowitz M, Nguyen BY, Gotuzzo N. Rapid and Durable Antiretroviral Effect of the HIV-1 Integrase Inhibitor Raltegravir as Part of Combination Therapy in Treatment Naive Patients With HIV-1 Infection:Results of a 48 Week Controlled Study[J]. J Acquir Immune Defic Syndr, 2007, 46(2): 125-133.
  • 5Jan Munch, Ludger Standker, Knut Adermann, et al. Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide[J]. Cell, 2007, 129: 263-275.
  • 6Si Z, Madani N, Cox JM, et al. Small-molecule inhibitors of HIV-1 entry block recep tor-induced conformational changes in the viralenvelope glycop roteins[J]. Proc Natl Acad Sci USA, 2004, 101:5036-5041.
  • 7MontembaultM, Vo-Thanh G, Deyine A, et al. A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor [J]. Bioorg Med Chem Lett, 2004, 14(6): 1543-1546.
  • 8F, Lori, A. Foli, L.M. et al. Virostatics: A New Class of Anti-HIV Drugs Current Medicinal Chemistry, 2007, 14: 233-241.
  • 9Pozniak, A. L. Tenofovir disoproxil fumarate emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antirelroviral-naive patients. J. Aquir[J]. Immune Defic, 2006, 43, 535-540.
  • 10王珍燕,卢洪洲.HIV-1非核苷类反转录酶仰制剂依非韦伦[J].世界临床药物,2007,28(11):680-683. 被引量:19

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