磷酸化STAT3和磷酸化ERK1/2在皮脂腺癌中的过度表达

Overexpressions of Phosphorylated-STAT3 and PhosphorylatedERK1/2 Protein in Sebaceous Carcinoma

目的:了解磷酸化细胞信号传导与转录活化因子3(STAT3)及磷酸化细胞外信号调节激酶(ERK1/2)蛋白在皮脂腺癌中表达的意义。方法:采用免疫组化ABC的方法检测了磷酸化STAT3和磷酸化ERK1/2蛋白在17例皮脂腺癌和20例皮脂腺瘤包埋切片中的表达。结果:在17例皮脂腺癌包埋切片中有14例p-STAT3表达阳性,13例p-ERK1/2表达阳性,而在20例皮脂腺瘤中有2例p-STAT3表达阳性,3例p-ERK1/2表达阳性;p-STAT3和p-ERK1/2在皮脂腺癌中的阳性表达明显高于它们在皮脂腺瘤中的阳性表达(均为P<0.01)。结论:p-STAT3和p-ERK1/2在皮脂腺癌的肿瘤形成机制中起重要作用。

Objective： To investigate the expression of phosphorylated signal tranducers and activators of transcription （p-STAT3） and phosphorylated extracellular signal-regulated kinase （p-ERK 1 / 2） in sebaceous carcinoma. Methods： By immunohistochemistry ABC staining of formalin-fixed, paraffin-embedded tissue sections of human sebaceous carcinoma （n= 17） and human sebaceous adenoma （n=20）, the expression of p-STAT3 and p- ERK1/2 was examined. Results： While the expressions of p-STAT3 were positive in 14 of 17 sebaceous carcinoma samples, only 2 out of 20 were found to be positive in sebaceous adenoma. On the contrary, p-ERK1/2 was positively expressed in 13 out of 17 cases of the sebaceous carcinoma sample, but only three cases showed the positive results in the sample of sebaceous adenoma. Conclusion： The evidence provided in this study suggests that the overexpressions of p-STAT3 and p-ERK1/2 play an important role in the oncogenesis of sebaceous carcinoma.