小多孢菌次级代谢产物的研究

Secondary metabolism of Micropolyspora sp.

目的:研究小多孢菌(Micropolysporasp.)次级代谢产物的化学成分。方法:应用多种色谱方法进行分离和纯化,并用NMR、IR和MS等方法解析其化学结构。结果:从小多孢菌次级代谢产物中分离到2个化合物,它们的结构分别被鉴定为:17-demethyl-lebrastatin(1)和4,6-二甲氧基-3-(3,5-二甲氧基苯基)-2-(4-甲氧基苯基)-1-氢-茚-1-酮(2)。结论:化合物1是新化合物。

Aim：To study the chemical constituents from the secondary metabolism of Micropolyspora sp.. Methods： Some chromatographic methods were used to separate the chemical constituents whose structures were identified by NMR, IR and MS. Results： Two compounds from the secondary metabolism of Micropolyspera sp. were identified as 17-demethyl-lebrastatin（ 1 ） and 4, 6-dimethoxy-3- （ 3,5- dimethoxy-phenyl）-2- （4-methoxy-phenyl）-indene- 1-one （ 2 ）. Conclusion：Compound 1 is a new compound.