HBsAg阳性孕妇肌肉注射HBIG预防HBV宫内感染研究

Study on the preventive effect of HBIG injection in pregnant women with HBsAg on intrauterine infection of HBV

目的：探讨经母体对胎儿进行乙肝免疫球蛋白（HBIG）被动免疫预防慢性乙型肝炎病毒（HBV）宫内感染的效果。方法：以在太原市传染病医院进行产前检查及分娩的HBsAg阳性孕妇96例作为HBIG注射组（自妊娠28周起多次肌肉注射HBIG 200IU），同期分娩但未进行产前检查HBsAg阳性孕妇59例作为对照组，采集新生儿出生24h内且未注射HBIG的股静脉血，检测HBV血清学标志物，分析比较注射与未注射HBIG的HBsAg阳性孕妇及注射HBIG孕妇不同注射次数间其新生儿HBV宫内感染的发生情况。结果：HBIG注射组HBV宫内感染率（12．5％，12／96）、HBsAg阳性率（10．2％，7／96）、HBVDNA阳性率（7．3％，7／96）均低于未注射组，但差异无显著性（P〉0．05）；将注射次数分为0～1次、2～3次和4～5次三个等级进行分析，HBV宫内感染率、HBsAg阳性率和HBVDNA阳性率随HBIG注射次数增加而减少，但差异无显著性（P〉0．05）。结论：初步提示HBsAg阳性孕妇产前注射HBIG及增加HBIG注射次数可能降低HBV宫内感染的发生。

Objective：To study the effect of passive immunization of fetus by injection of mother with HBIG on .preventing HBV intrauterine infection. Methods：Ninty-six pregnant women with HBsAg positive was treated with HBIG 200 IU every month from week 28,59 cases without HBsAg as control. HBV intrauterine infetion was studied by detecting HBsAg and HBV DNA in newborns before HBIG injection in 24 hours after birth. Analyse the HBV intrauterine infection rate between the 2 groups,and also among the different injection times. Results：Rate of HBV intrauterine infection,HBsAg positive and HBV DNA positive in HBIG injection group were lower than control, but there was significant difference. Dividing the HBIG injection number of times into three groups 0-1,2- 3 and 4-5, with it＇s increasing. Rate of HBV intrauterine infection,HBsAg positive and HBV DNA positive was decreasing,there was but there was significant difference. Conclusion ：The intrauterine infection of HBV could be possibly decreased by HBIG injection and increasing injection number of times during pregnancy.