摘要
缺血性心脏病是影响人类健康的主要疾病之一,尽管血管再灌注治疗能挽救顿抑心肌,但无法使心肌细胞再生。由于心肌细胞的再生能力有限,梗死区域由瘢痕组织代替。近年来,研究显示干细胞能分化成心肌细胞,从而给治疗缺血性心脏病带来希望。但一部分研究表明:移植干细胞易引发心律失常,这主要是由于其电生理异常所致,机制主要包括:自律性增加,缓慢传导以及触发活动。本文对近年来干细胞心肌细胞分化所致心律失常的研究进行综述。
Ischemic heart disease is one of the leading causes of.mortality in the world. In spite of the fact that vascular reperfusion therapy can rescue the stunned myocarolium yet the infracted area is substituted by scar tissue as the cardiomyocytes without regeneration ability. Recently, stem cells have shown the ability to engraft in areas of myocardial damage, differentiate into cardiomyocytes. Observations suggested the possibility of cardiac cell transplantation as a treatment for cardiomyopathy. If transplanted myocyte electrophysiology is abnormal, they could contribute to arrhythmias. Mechanisms by which they might increase the likelihood of arrhythmias include demonstration of persistent automaticity, slow conduction, or triggered activity. And this article reviews recent investigations which focused on arrhythmias of the stem cell derived cardiomyocytes.
出处
《实用心脑肺血管病杂志》
2007年第6期466-469,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
