围绝经期以后妇女雌激素的替代疗法

Estrogen Replacement Therapy after Peri-menopause

目的观察雌激素替代治疗更年期综合征的疗效。方法将60例更年期综合征患者随机分成2组,分别给与天然雌激素+安宫黄体酮或谷维素治疗0.5～2a,用汉密尔顿抑郁量表(HAMD)评定疗效。结果HAMD减分率实验组为(59·8±7·7)%,对照组为(15·3±5·4)%,2组相比,差异有统计学意义(t=25.92,P<0·01);雌激素治疗后显效率(痊愈+显著好转)为86.6%,对照组为3%,2组比较,差异有统计学意义(χ2=35.31,P<0·01)。结论雌激素治疗更年期综合征有效。

[ Objective] To observe the efficacy of estrogen replacement therapy in treating climacteric syndrome. [ Methods ] 60 cases of climacteric syndrome were randomly divided into two groups and treated respectively with nilestrol plus medroxyprogesterone and gammariza alone for 0.5 to 2 years ; HAMD was used to evaluate the efficacy. [ Results] The subtraction rate of HAMD in the case group and the control were （ 59.8 ± 7.7 ） % and （ 15.3 ± 5.4 ） % respectively, the difference was significant （ P 〈 0. 01 ） ; the effectual rate of the case group and the control were 86.6% and 3% respectively, the difference was significant （ P 〈 0. 01 ）. [ Conclusion ] Estrogen replacement therapy is effective in treating climacteric syndrome.