摘要
目的探讨中高度非霍奇金淋巴瘤预后改善。方法对200例经化学治疗的患者进行预后因素分析。应用多因素Cox模型分析年龄、性别、临床分期、B症状、淋巴结外病灶、骨髓侵犯、巨大肿块、体力状况和病理恶性度等因素。结果体力状况、结外病灶、病理恶性度和巨大肿块对预后具有显著意义。按预后指数(PI)将患者分为低危组(PI为-2.43~-1.30)、中危组(PI为-1.29~1.0)和高危组(PI>1.0),其5年生存率分别为76.0%、21.6%及7.4%。结论预后分组可用于指导治疗,据此,高危组可考虑采用更强烈化疗及自体造血干细胞移植,中危组及低危组可采用标准化疗方案。这将有助于改善患者的预后。
Objective To predict the prognostic factors and to improve the response and survival in intermediate grade and high grade non Hodgkin lymphoma (NHL). Methods 200 patients with intermediate grade and high grade NHL were treated with chemotherapy. A multivariate Cox model was used to analyse the prognostic factors that significantly affect the treatment outcome. The variables examined included: sex, age, clinic stage of disease, B symptoms, extranodal sites, bone marrow involvement, tumor bulk, performance status (ECOG) and malignancy grades. Results Multivariate analysis showed that performance status, the number of extranodal sites, pathologic malignancy grade and tumor bulk were significantly independent prognostic factors. These factors were put together to construct a prognostic index formula. The index partitioned the patients into low risk group (PI-2 43~-1 30), intermediate risk group (PI-1 29~1 0) and high risk group (PI>1 0) giving 5 year survival rates of 76.0%, 21.6% and 7.4%, respectively. Conclusion The prognostic index formula and subgroups could serve as a reference to distinguish patients requiring more intensive chemotherapy and autologous stem cell transplantation from those who should be treated with standard regimens in order to improve the prognosis.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1997年第3期212-214,共3页
Chinese Journal of Oncology
关键词
非霍奇金淋巴瘤
预后
Lymphoma, non Hodgkin′s Models, statistical Prognosis