摘要
应用电镜细胞化学方法,从心肌细胞超微结构和细胞色素C氧化酶的改变方面.观察了天保宁对阿霉素所致心肌细胞线粒体损伤的保护作用.阿霉素造成的大鼠心肌细胞肌原纤维排列紊乱,线粒体肿胀,嵴断裂及细胞色素C氧化酶活性降低,可明显地被抗氧化剂天保宁所防止,说明天保宁能够清除阿霉素所产生的有害自由基,对心肌细胞起保护作用.
The protective effect of taponin on heart mitochondria against adriamycin cytotoxicity was investigated by electron microscopic cytochemical method. The disorder of myofibrills; swelling of mitochondria with broken cristae and decrease of cytochrome C oxidase activity caused by adriamycin were prevented by the administration of taponin. The results suggested that taponin could scavenge the toxic radicals generated by adriamycin and protect the cardiac myocytes.
出处
《解剖学杂志》
CAS
CSCD
北大核心
1997年第2期148-151,共4页
Chinese Journal of Anatomy
