大川芎方治疗偏头痛效应组分的提取、纯化工艺研究

Study on Extraction and Purification of Active Parts from Da Chuan Xiong Fang for Treatment of Migraine

目的:对大川芎方治疗偏头痛效应组分的提取、纯化工艺进行研究。方法:采用单因素及正交试验设计分别考察了川芎中含阿魏酸效应组分、天麻中含天麻素效应组分的提取、纯化工艺,并用药理实验评价其药理效应。结果:含阿魏酸效应组分的出膏率为1.67%,其中阿魏酸含量为5.82%;含天麻素效应组分的出膏率为5.38%,其中天麻素含量为8.45%。结论:大川芎方治疗偏头痛的效应组分得到有效的提取、纯化,且工艺简单、稳定。

Objective： To study on the process of extraction and purification of active parts from Da Chuan Xiong Fang for treatment of migraine. Methods ： the process of extraction and purification of active parts with ferulic acid and gastrodin were optimized respectively by direct comparison and orthogonal design. ReSults： Paste rate of active parts with ferulic acid was. 1.67% and the content of ferulic acid was 5.82%. Paste rate of active parts with gastrodin was 5.38% and the content of gastrodin was 8.45%. Conclusion： Active parts from Da Chuan Xiong Fang for treatment of migraine are extracted and purified effectively.