胎儿胃肠胰组织阿片肽的分布和发育

ONTOGENY OF OPIOID PEPTIDES IN HUMAN FETAL GUT AND PANCREAS

用放射免疫法测定了24例10～40周胎儿胃、十二指肠、空肠、回肠、结肠及胰腺内β-内啡肽、甲硫脑啡肽、亮脑啡肽的浓度.发现10周胎儿胃肠胰组织内已有少量β-内啡肽、甲硫脑啡肽、亮脑啡肽存在;胃内β-内啡肽发育的高峰浓度在15～20周,小肠及胰腺高峰浓度在21～25周,结肠的高峰浓度在26～30周;胃肠胰组织内甲硫脑啡肽及亮脑啡肽的发育高峰浓度均在21～25周;β-内啡肽、亮脑啡肽及甲硫脑啡肽在胎儿发育期间,以胃窦、小肠上段及胰腺浓度较高,回肠、结肠浓度较低;在相同胎龄同一器官内甲硫脑啡肽的浓度比亮脑啡肽的浓度高0.5～3倍,而比β-内啡肽高2～25倍.对上述阿片肽在胎儿胃肠胰组织的分布及发育过程进行了讨论.

β-Endorphin(β-EP), methionine-enkephalin(M-ENK) and leucine-enkephalin(L-ENK) were determined in the various gut regions and the pancreas in human fetuses by radioimmunoassay. The results were as follows; (1)The peak concentration of β-EP appear in the stomach at 16-20 week, at 21-25 week in the small intestine and pancreas peak, and at 26-30 week in the colon. (2) The concentration of M-ENK appear in various gut regions and the pancreas at 21-25 week.(3) During gestation, the concentration of M-ENK was higher in the antrum and the duodenum, but lower in the colon. (4) The ontogeny of L-ENK in various gut regions and the pancreas was similar to that of M-ENK. (5) In the same tissue the concentration of M-ENK was 2-25 times higher than that of β-EP, and 0. 5-3 times than that of L-ENK.