“肾为先天之本”后代鼠行为遗传的脑形态学表征

Relationship Between Brain Morphological Characteristics of Behavioral Heredity in Mice and the Theory that the Kidney Is the Congenital Life Basis

引入了行为遗传学的实验方法 ,并用大脑形态学的微观指标来作为行为遗传的表征 ,采用猫吓孕鼠“恐伤肾”造模 ,受恐吓母鼠所生下一代初生鼠与对照组比较 ,大脑皮质厚度变薄 (P <0 .0 1) ,尤其是大脑皮质中的分子层成倍变薄 (P <0 .0 1) ,神经元数量减少 10 % (P <0 .0 5) ,且树突减少 ,这些新的发现符合中医“恐伤肾”、“肾通于脑”的理论 ,并可作为行为遗传的客观表征之一。

The methods used in experiments on behavioral genetics were adopted in this study,and the behavioral heredity was studied by using the microscopic criteria established for studying cerebral morphology. The model of renal damage by terror was induced by using a cat to threaten pregnant mice .The primary mice produced by the model group were compared with those produced by the control group, and the results showed that in the mice of the model group, the cerebral cortex was much thinner; in addition, the number of neurons of cerebral cortex showed a decrease of 10% with a decreased number of dendrites. These finds can be used as criteria for studying the TCM theory that terror damages the kidney and the kidney connects the brain on the basis of behavioral genetics.