吸烟、饮酒与精子形态的相关性及双因素对精子形态影响

CORRELATION BETWEEN SMOKING,ALCOHOL CONSUMPTION AND SPERM MORPHOLOGY AND EFFECT OF DOUBLE FACTORS ON SPERM MORPHOLOGY

[目的]探讨吸烟深度、饮酒量与精子形态的相关性及吸烟饮酒双因素对精子形态影响。[方法]659例男性不育患者,分为有吸烟史(263)、经常饮酒(137)和吸烟饮酒(259)3组,生育组(329)为已有生育的健康男性。患者自愿填写问卷,对吸烟、饮酒患者资料分析,采用精子形态检测系统下人工修正方法进行精子形态分析。[结果]吸烟年数与正常形态精子百分率之间有显著负相关关系(r=-0.155,P﹤0.001);每天饮酒的量(g/d)与正常形态精子百分率之间有显著负相关关系(r=-0.146,P﹤0.05);吸烟饮酒组正常形态精子百分率显著低于吸烟组(P﹤0.005),亦显著低于饮酒组(P﹤0.01)。[结论]长期吸烟、大量饮酒影响精子形态,吸烟饮酒双因素对精子形态影响大于单一因素的影响。

[Objective] To study the correlation between smoking, alcohol consumption and sperm morphology and the effect of double factors on sperm morphology. [ Methods] Sperm samples were obtained from 659 male infertility patients, which were divided into somking group （263 people）, alcohol drinking group （ 137 people） and smoking and alcohol drinking group （259 people）, and 329 healthy fertile men were selected as controls. The date obtained from questionnaires filled out by patients voluntarily were analyzed. The sperm morphology analysis using semiautiomatic sperm morphology analyzer was performed. [ Results] There was a significant negative relation between the percentage of sperm with normal morphology and the years of smoking （r = -0.155, P 〈 0.001 ）. And there was aslo a significant negative relation between the percentage of sperm with normal morphology and daffy intake of alcohol （r = -0.146, P〈 0.05）. The percentage of sperm with normal morphology in smoking and drinking group was significantly lower than that in smoking group or drinking group （P〈 0.005, P〈 0.01）. [Conclusions ] Long-term smoking and heavy drinking make the percentage of sperm with normal morphology decrease. Double factors influence sperm morphology more greatly than univariate smoking or drinking.