桉黄生肌止痒软膏对大白鼠烫伤模型的实验研究

EXPERIMENTAL STUDY ON EFFECTS OF EUCALYPTUS PASTE ON SCALDED MODEL OF WISTAR RATS

[目的]探讨桉黄生肌止痒软膏对大白鼠烫伤模型的治疗效果。[方法]Wistar大白鼠,雌雄各半,体重(250±50)g,随机分成5组,每组10只,深Ⅱ度烫伤模型。75%桉黄生肌止痒软膏组、50%桉黄生肌止痒软膏组、25%桉黄生肌止痒软膏组、磺胺嘧啶银组、凡士林对照组。[结果]75%、50%桉黄生肌止痒软膏组,21d后,创面愈合且有皮肤附属器再生,其疗效与磺胺嘧啶银组差异无统计学意义(P﹥0.05);25%桉黄生肌止痒软膏组21d后,创面Ⅱ期愈合,缺乏皮肤附属器,其疗效不及磺胺嘧啶银组(P﹤0.05);凡士林组21d后创面愈合情况差。[结论]桉黄生肌止痒软膏除具有生肌止痒的功效外,抗炎消菌作用也十分明显。

[Objective] To study the therapeutic effects of eucalyptus paste on scalded model of Wistar rats. [Methods] A total, of 50 Wistar rats, weighing （250 ± 50） g, half males and half females, deep Ⅱ scalded model, were randondy divided into five group （10 rats each group）, which were respectively treated with 75% eucalyptus paste, 50% eucalyptus paste, 25% eucalyptus paste, SD-Ag and Vaseline. [ Results] After treament for 21 days, for 75% eucalyptus paste group and 50% eucalyptus paste group, the wounds were healed and contaneous appendages regenerated, the therapeutic effect was not significandy different from that of SD-Ag group （P 〉 0.05） ; for 25% eucalyptus paste group, the wounds achieved secondary healing but without contaneous appendages regeneration, the therapeutic effect was worse than that of SD-Ag group （P 〈 0.05） ： and the curative effect of Vaseline group was weak. [ Conclusions ] Eucalyptus paste can not only promote tissue regeneration and alleviate itching, but also has anti-inflammatory action and bactericidal action.