复方新霉素乳膏敷脐治疗婴幼儿细菌性腹泻及其药代动力学观察

Study on treatment of infantile bacterial diarrhoea with compound neomyocin emulsion plaster and its pharmacokinetic

目的：探索治疗婴幼儿腹泻的有效给药途径。方法：采用中西医结合的方法，自行研制复方新霉素乳膏外敷脐部治疗婴幼儿细菌性腹泻１１２例，同时进行药代动力学监测，并与口服庆大霉素对照组７８例作比较。结果：治疗组疗效明显优于对照组。第１天和第３天止泻率及平均治愈天数，治疗组分别为２３．２％、８９．３％和２．３０±０．８３天；对照组分别为１．３％、１７．９％和４．４０±１．０４天，经统计学处理两组有显著性差异（Ｐ＜０．０１）。治疗组监测３０例尿液药物浓度，用药后尿液药物浓度均有不同程度的增高，并随时间的延长而增加。结论：本疗法符合中医的内病外治——敷脐疗法和西医药物经皮伤药透皮吸收双重机制，疗效显著，又具有无痛苦、简便易行、安全可靠、患儿易接受等优点。

Objective:To investigate the appropriate administration route on treatment of infantile diarrhoea.Methods:112 cases of infantile bacterial diarrhoea were treated by means of navelcovering with compound neomyocin emulsion plaster and compared with 78 cases,who were treated with convention.In other hand,the examination of pharmacokinetic was made.Results:①Therapeutic effect is apparent superior in treatment group to control group.②Stopping rate of diarrhoes is 23 2% and 89 3% on first and third day,respectively,in treatment group,but 1 3% and 17 9%,respectively,in control group ( P <0 01).③The average duration of cure is 2 30±0 83 days in treatment group and 4 40±1 04 days in control group( P <0 01).④Neomycin concentration in urine were examined for 30 cases of treatment group,it suggested that drug level in urine was increased to a greater or less extent.Conclusions:Above therapeutic pattern is accordant with navelcovering theory of traditional Chinese medicine and mechanism on drug absorption through skin of western medicine.It showed that navelcovering route may have much advantage include remarkable effect,no painful,simple,safe and acceptable for ill infant.