期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PPAR-γ对动脉粥样硬化中单核/巨噬细胞的作用

下载PDF
导出
摘要 过氧化物酶体增殖激活受体γ(peroxisome proliferafors-activated receptor gamma PPARγ)是核受体超家族成员之一,参与体内多种生理病理过程,近年来研究表明,该类受体激活后还可以对动脉动脉粥样硬化病变所涉及的病理途径进行调节。目前其对血管局部单核/巨噬细胞的调节作用仍存在许多争议之处,其激活剂可能对动脉粥样硬化的防治具有重要意义。
作者 张绍洁 吴黎明
机构地区 福建医科大学附属协和医院心内科
出处 《中国分子心脏病学杂志》 CAS 2007年第1期47-50,共4页 Molecular Cardiology of China
关键词 过氧化物酶体增殖激活受体Γ 动脉粥样硬化 单核/巨噬细胞
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献24

  • 1[1]Issemann I,Green S.Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.Nature,1990,347(6294):645-650.
  • 2[2]Nagy L,Tontonoz P,Alvarez JG,et al.Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma.Cell,1998,93(2):229-240.
  • 3[3]Neve BP,Fruchart JC,Staels B.Role of the peroxisome proliferators-activated receptors (PPAR) in atherosclerosis.Biochem Pharmacol,2000,60(8):1245-1250.
  • 4[4]Pasceri V,Cheng JS,Willerson JT,et al.Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs.Circulation,2001,103(21):2531-2534.
  • 5[5]Han KH,Chang MK,Boullier A,et al.Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferators-activated receptor gamma.J Clin Invest,2000,106 (6):793 -802.
  • 6[6]Goetze S,Eilers F,Bungenstock A,et al.PPAR activators inhibit endothelial cell migration by targeting AKt.Biochem Biophys Res Commun,2002,293 (5):1431-1437.
  • 7[7]Takata Y,Kitami Y,Yang ZH,et al.Vascular inflammation is negatively autoregulated by interaction between CCAAT/enhancer-bind-ingprotein-delta and peroxisome proliferators-activated preceptor-gamma.Circ Res,2002,91(5):427-433.
  • 8[8]Chinetti G,Griglio S,Antonucci M,et al.Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.J Biol Chem,1998,273 (40):25575-25580.
  • 9[9]Marx N,Sukhova G,Murphy C,et al.Macrophages in human atheroma contain PPAR gamma:differentiation-dependent peroxisomal proliferator-activated preceptor-gamma (PPAR gamma) expression and reduction of MMP-9 activity through PPAR gamma activation in mononuclear phagocytes in vitro.Am J Pathol,1998,153 (1):17-23.
  • 10[10]Moore KJ,Rosen ED,Fitzgerald ML,et al.The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.Nat Med,2001,7(1):41-47.

二级参考文献29

  • 1[1]Freeman, M.W, Ekkel, Y., Rohrer, L,et al.Expression of type Ⅰ and type Ⅱ bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.Proc Natl.Acad.Sci,1991,88:4931- 4935
  • 2[2]Kunjathoor VV, Febbraio M,Podrez EA.Scavenger receptors class A-Ⅰ/Ⅱ and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages.J Biol Chem,2002, Dec 20;277 (51):49982- 49988
  • 3[3]Reaven EL, Zhan A, Nomoto A, et al.Expression and microvillar localization of scavenger receptor class B, type I (SR-BⅠ) and selective cholesteryl ester uptake in Leydig cells from rat testis.J Lipid Res,2000,Mar;41(3):343-356
  • 4[4]Resnick, D,Chatterton, JE,Schwartz, K,et al.Structures of class A macrophage scavenger receptors.Electron microscopic study of flexible, multidomain, fibrous proteins and determination of the disulfide bond pattern of the scavenger receptor cysteine-rich domain.J.Biol.Chem,1996,271: 26924-26930
  • 5[5]Ninetta K, Stuart R, Alan D,et al.Class A Scavenger Receptor-mediated Adhesion and Internalization Require Distinct Cytoplasmic Domains.J Biol Chem,2003,278(36),34219-34225
  • 6[6]Boullier A, Bird DA, Chang MK, et al.Scavenger receptors, oxidized LDL, and atherosclerosis.Ann N Y Acad Sci,2001,Dec;947:214-222.
  • 7[7]Hsu H.Y, Hajjar D.P, Khan K.M,et al.Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling pathway.J Biol Chem,1998, 273:1240-1246
  • 8[8]Sakai M, Kobori S, Miyazaki A,et al.Macrophage proliferation in atherosclerosis.Curr Opin Lipidol,2000,Oct;11(5):503-509
  • 9[9]Ishibashi, S, T.Inaba, H.Shimano, et al.Colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in humanderived macrophages.J.Biol Chem,1990,265:14109-14117
  • 10[10]Van Lenten, B.J, and A.M.Fogelman.Lipopolysac-charide-induced inhibition of scavenger receptor expression in human monocyte-macrophages is mediated through tumor necrosis factora.J.Immunol,1992,148:112-116

共引文献6

中国分子心脏病学杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部