摘要
[目的]为了正确评价不同浓度的磺胺喹恶啉对雏鸡的生长发育和对各器官组织特别是免疫器官的影响,并分析其中毒机理。[方法]以0.2%、0.5%2个浓度剂量的复方磺胺喹恶啉钠分别给7日龄海兰褐蛋雏鸡连续饮水14d,建立磺胺喹恶啉钠雏鸡人工中毒试验模型,试验鸡只按正常免疫程序免疫新城疫,观察鸡群的临床表现,分别在用药后第7天和第14天分别剖杀试验雏鸡,称量体重,测量免疫器官指数和新城疫抗体水平,观察剖检病变及病理组织学变化,评价应用磺胺喹恶啉钠对雏鸡的影响。[结果]雏鸡饮用0.2%磺胺喹恶啉连用1周是安全的,连用2周发生轻度中毒的表现;雏鸡饮用0.5%磺胺喹恶啉很快发生中毒表现,磺胺喹恶啉中毒可使雏鸡出现严重临床症状,机体免疫机能下降,免疫器官发育受阻,抗体水平降低,肌肉出血,肝、肾等实质器官变性肿胀。[结论]该研究为正确使用磺胺喹恶啉、促进养鸡业的发展提供了依据。
The aim of the experiment was to correctly evaluate the effect of different concentrations of suffaquinoxaline on the growth development and various organs of chicks, especially the immune organs. The paper analyzed the intoxication function. Two concentrations of sulfaquinoxaline at 0.2 % and 0.5 % were given to Hyline brown-egg chicks at the age of 7 days for duration of 14 days. The experiment has established the model of sulfaquinoxaline chick intoxication experiment. The chicks under the experiment have been vaccinated with Newcastle disease according to normal immune procedure. After observation of the clinic symptoms, chicks were kilied on day 7 and day 14, then weighed, measured the index of the immune organs and the antibody level of Newcastle disease. The experiment has observed the pathologic lesions and histopathological changes and evaluated the effect of sulfaquinoxaline on chicks, This study has provided scientific background for the correct use of sulfaquinoxaline and promoting the development of poultry industry.
出处
《安徽农业科学》
CAS
北大核心
2007年第20期6085-6087,共3页
Journal of Anhui Agricultural Sciences
关键词
磺胺喹恶啉
雏鸡
中毒
Sulfaquinoxaline
Chicks
Intoxication
