乙型肝炎及原发性肝癌患者sIL-2R的变化

Changes of serum sIL 2R in patients with hepatitis B and primary hepatocellular carcinoma

目的探讨ｓＩＬ２Ｒ水平与乙型肝炎病情的关系及其在原发性肝癌早期诊断中的价值．方法以ＥＬＩＳＡ法动态检测１１３例乙型肝炎及６例原发性肝癌患者ｓＩＬ２Ｒ水平，另选３１例健康体检者作对照组．结果以ｑ检验、ｔ检验进行统计学处理（微机处理，ＰＯＭＳ２００版）．结果各型乙型肝炎ｓＩＬ２Ｒ水平均显著高于正常对照（ＮＣ）组（Ｐ＜００１），其顺序依次为：ＨＣＣ＞ＣＳＨ＞ＣＨ（ＩＩ）＞ＬＣ＞ＣＨ（ＩＩ）＞ＡＨ＞ＣＨ（Ｉ）＞ＮＣ．ＨＣＣ组ｓＩＬ２Ｒ均值达正常值的２倍以上，且与ＣＨ（Ｉ），ＣＨ（Ｉ），ＡＨ间存在显著性差异（Ｐ＜００１，＜００５及＜００５）；ＣＨ（ＩＩ）组显著高于ＣＨ（Ｉ）组（Ｐ＜００１）．ＨＢｅＡｇ阳性组及ＨＢＶＤＮＡ阳性组ｓＩＬ２Ｒ水平显著高于阴性组．结论ｓＩＬ２Ｒ是监测乙型肝炎病情、ＨＢＶ复制及诊断早期原发性肝癌的一项敏感标志．

AIM To study the significance of the changes of serum sIL 2R in patients with hepatitis B (HB) and primary hepatocellular carcinoma (HCC). METHODS Serum sIL 2R levels were detected by ELISA in 113 patients with hepatitis B, 6 patients with HCC and 31 controls. The results were evaluated statistically with the Newana multiple range and t test (PC, POMS2 00). RESULTS The level of sIL 2R was significantly increased in patients with HB and HCC as compared with normal controls (NC), in the following order: HCC>CSH>CH(Ⅲ)>LC>CH(Ⅱ)>AH>CH(Ⅰ)>NC ( P <0 01). The mean of sIL 2R in HCC was double of normal controls, and the difference was significant as compared with CH(Ⅰ), CH(Ⅱ), AH( P <0 01, <0 05 and <0 05). The sIL 2R level of CH(Ⅲ) was significantly higher than CH(Ⅰ) ( P <0 01). The level of sIL 2R was notably different between positive and negative HBeAg or HBV DNA groups. CONCLUSION Serum sIL 2R is a sensitive marker in assessing the patient′s condition, prognosis, HBV duplication and diagnosing early HCC.