外周血有核细胞中t-PA mRNA的表达与脑梗死患者的相关性研究

Study on Correlation between Expression of t-PA-mRNA in Peripheral Blood Nucleated Cells and Patients with Cerebral Infarction

目的:探讨脑梗死患者与t-PA mRNA表达的关系。方法:用逆转录-PCR(RT-PCR)法检测40例脑梗死患者和40例正常对照者外周血有核细胞中t-PA mRNA的表达。结果:脑梗死患者组外周血有核细胞中t-PA mRNA的表达明显增强,同正常对照组比较差异有显著性(P<0.01)。结论:外周血有核细胞中t-PA mRNA的表达增强与脑梗死密切相关,可作为脑梗死的辅助诊断指标;并有可能作为脑梗死疗效的动态监测指标。

Objective ：To investigate the relationship between patients with cerebral infarction and the expression of t-PA-mRNA. Methods：The t-PA mRNA in peripheral blood nucleated cells was detected by RT-PCR. Result：The mRNA expression levels of t-PA of peripheral blood nucleated cells in the patients with cerebral infarction group was remarkable high and notable difference was shown comparing with those of the normal group （P〈0.01）. The mRNA expression of t PA of peripheral blood nucleated cell had a close correlation with patients with cerebral infarction. Conclusion.The mRNA expression of t-PA in the peripheral blood nucleated cells is closely correlated with the patients with cerebral infarction, which may be an early assistant indicator of diagnosis and treatment in patients with cerebral infarction.