摘要
目的:探讨氟达拉宾治疗慢性淋巴细胞白血病(CLL)诱发嗜酸细胞增多症的临床特点、诊断及治疗方法,减少误诊误治的发生。方法:总结1例诊断及治疗经过,结合文献对临床特点进行复习。结果:此病多发生在用药后2.4个疗程,大多无症状,少数患者发生皮损,皮损重者可应用激素及抗组胺药治疗。结论:氟达拉宾及2-氯脱氧腺苷(2-CdA)治疗淋巴增殖性疾病可诱发嗜酸细胞增多症,用药期间监测血象有助于早期诊断。
Objective：To discuss the clinical characteristics ,diagnosis and treatment of eosinophilia induced by fludarabine in treatment of chronic lymphocytic leukaemia. Method：We summarized the process of the diagnosis and treatment of one case of fludarabine-induced eosinophilia and retrospectively studied related literature. Results：This disease usually occurred after 2.4 courses of the therapy. Most patients were clinically asymptomatic and some patients might occur skin lesions. Those patients who occurred eosinophilia with serious skin lesions required antihistaminic drugs and/ or corticosteroids. Conclusion：Eosinophilia can be induced by fludarabine and 2-chlorodeoxyadenosine （2-CdA） during the treatment of lymphoproliferative diseases. It should be necessary to monitor the eosinophil in order to make diagnosis earlier.
出处
《中国误诊学杂志》
CAS
2007年第16期3702-3704,共3页
Chinese Journal of Misdiagnostics
