特发性血小板减少性紫瘢血清氧自由基水平

Serum Level of Oxygen Free Redicals in Patients with Idiopathic Thrombocytopenic Purpura

目的：探讨氧自由基与特发性血小板减少性紫瘢（ＩＴＰ）关系，观察维生素Ｃ对氧自由基的清除作用。方法：采用放免法测定ＩＴＰ血清丙二醛（ＭＤＡ），总超氧化物歧化酶（ＴＳＯＤ）、锰超氧化物歧化酶（ＭｎＳＯＤ）、谷胱甘肽过氧化物歧化酶（ＧＳＨＰｘ）水平，并给予维生素Ｃ治疗。结果：３２例ＩＴＰ血清ＭＤＡ、ＴＳＯＤ、ＭｎＳＯＤ水平较正常人高（Ｐ＜００１），ＧＳＨＰｘ水平正常（Ｐ＞００５）；维生素Ｃ治疗后，氧自由基水平下降（Ｐ＜００１）。结论：氧自由基水平升高可能与ＩＴＰ有关，维生素Ｃ具有清除氧自由基的作用。

Objective: The aim is to investigate the correlation between oxygen free redicals and idiopathic thrombocytopenic purpura(ITP),and the redical scavenge effect of vitmin C was observed.Methods: Serum levels of malonaldehyde (MDA) and superoxide dismutase (SOD),glutathione peroxidase (GSH Px) were detected in 32 cases of ITP by RIA,and treatment of vitmine C was given.Results: In ITP Serum level of MDA was higher than that in normal individual ( P<0.01 ),T SOD,Mn SOD were lower ( P <0.01), serum level of GSH Px was at normal ( P >0.05).After treatment with vitmine C,the level of oxygen free redical was decreased( P <0.01).Conclusion:Oxygen free redical may be related to ITP,vitmine C has effect of redical scavenge.