摘要
目的建立能用于科学研究的放射性脑损伤动物模型。方法选用40只新西兰兔作为动物实验模型,随机分为4组:10Gy、15Gy、20Gy和30Gy组。分别在CT定位下建立三维重建图像资料,应用三维适形放射治疗系统(3D-TPS)精确设计治疗计划、优化照射靶区剂量分布,照射体积约1cm×1cm×1cm,6MVX线单次大剂量照射。结果3D-TPS的剂量分布曲线显示,受照区域剂量分布均匀,95%的等剂量曲线包绕100%靶区体积,受照体积为(1±0.03)cm3。结论动物模型受照区域产生剂量均匀、准确,可用于研究放射性脑损伤。
Objective To establish an animal model by which study on the brain radiation injuries. Methods Forth New Zealand rabbits were randomly divided four groups and irradiated by 6 MV X ray at a single dose of 10,15,20 and 30 Gy. Three-dimensional reconstructed images were set up assisted CT. The designation of therapy plans and adjustment of dose distributions on the same pre-irradiation target areas with the volume about l crnX 1 cruX 1 cm were all by ways of three dimensional conformal radiation therapy plan system（TPS）. Results The isodose curve showed that 100% target volume were covered with 95% isodose outline The dose distributions were uniform and the irradiation volume was about （1± 0. 03）cm^3. Conclusion The rabbit model appears to be an excellent model for study on the brain radiation injury.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第7期477-479,547,共4页
Cancer Research on Prevention and Treatment
关键词
动物模型
放射性脑损伤
适形放射治疗
Radiation brain injury
Animal model
Three dimensional conformal radiation therapy
