摘要
目的观察国产多西紫杉醇(TAT)联合亚叶酸钙/5-氟尿嘧啶(CF/5-Fu)及顺铂(DDP)治疗晚期胃癌的临床疗效与不良反应。方法41例晚期胃癌患者接受TAT与CF/5-Fu及DDP联合化疗:TAT75mg/m2,静滴1h,d1;CF100mg,静滴2h,d1～5;5-Fu500mg/m2,22h微泵持续静滴,d1～5;DDP25mg/m2,静滴,d1～3。28天为一个周期。治疗2个周期后评价疗效和不良反应。结果41例患者均可评价疗效。完全缓解2例,部分缓解23例,有效率61.0%。中位疾病进展时间7.5个月,中位生存期10.6个月,1年生存率41.5%。主要不良反应为骨髓抑制,脱发和周围神经炎。结论国产多西紫杉醇联合亚叶酸钙/5-氟尿嘧啶及顺铂治疗晚期胃癌缓解率高,毒副反应可以耐受。
Objective To evaluate the efficacy and toxicity of domestic Docetaxel in combination with Calcium Folinate/5-Fluorouracil and Cisplatin on advanced gastric cancer. Methods Forty-one patients with advanced gastric cancer were treated by Docetaxel 75 mg/m^2 on dr, Calcium Folinate 100mg on d1-5, 5-Fluorouracil 500mg/m^2 on d1-5, Cisplatin 25mg/m^2 on d1-3, with 28 days one cycle. The efficacy and adverse effect were evaluated after two cycles. Results Forty-one patients can be included for response rate. 2 showed complete response and 23 partial responses with an overall response rate of 61.0% （25/41）. Median time to progression was 7. 5 months, and 1-year survival rates was 41.5%0 with median survival time of 10. 6 months. The main adverse effect was myelosuppression, alopecia and peripheral neuritis. Conclusion The regimen of domestic Docetaxel combined with Calcium Folinate/5-Fluorouracil and Cisplatin for patients with advanced gastric cancer produced high response rate and its toxicity is well tolerable.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第7期526-527,共2页
Cancer Research on Prevention and Treatment
