Toll样受体与急性肺损伤研究进展

Research advances in Toll-like receptors and aute lung injury

急性肺损伤是由感染性和非感染性的炎症刺激因子启动的细胞内"瀑布式"反应所产生的,其治疗较为困难。Toll样受体在调节急性肺损伤后的炎症和修复机制方面扮演着重要的角色。通过由Toll样受体依赖的基础激动因子NF-κB和干扰素调节因子的激活以及其后的转录表达,产生了高水平的前炎症介质和低水平的抗炎症分子表达,最终导致了疾病的发生。无论Toll样受体在对抗肺损伤时是否起到了保护作用,对信号传导的修饰和调节都可能成为治疗靶向。

Acute lung injury, which occurs as a result of a cascade of cellular events initiated by either infectious or non-infectious inflammatory stimuli, is difficult to treat. And Toll-like receptors （TLRs） play a crucial role in the regulation and repair of inflammation after acute lung injury. Through TLR-dependent basal activations of NF-κB and interferon-regulatory factor and the following transcriptional events, an elevated level of proinflammatory mediators and a decreased expression of anti-inflammatory molecules were produced, which finally leads to the occurrence of the disease. Whether TLRs play a protective role against the agents or not, modification and regulation of signal transcription is likely to be a logical therapeutic target for acute lung injury.