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小型猪与梅山猪Prop1基因的比较分析 被引量:1

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摘要 Prop1是一种新发现的参与早期胚胎垂体发育的特异性转录因子。在人和动物均已发现由于该基因突变而引起的综合性垂体功能障碍,进而影响生长和繁殖。小型猪与梅山猪比较,其繁殖力和生长性能差异显著,为了了解这些差异的遗传基础,本试验对五指山猪、藏猪和版纳猪3种小型猪的Prop1基因进行克隆测序,并与已知梅山猪的序列进行对比,结果为:五指山猪与藏猪外显子1第69位发生G-A碱基替换,编码同义氨基酸;藏猪外显子2第115位发生A-G碱基替换,编码终止密码子;藏猪与版纳猪外显子3第466位和第631位均发生C-T碱基替换,第466位藏猪编码同义氨基酸;第631位版纳猪编码丝氨酸(TCC),梅山猪编码脯氨酸(CCC),即2种猪的Prop1基因产物不同。在Prop1基因终止密码下游250左右有一个腺苷酸丰富区,五指山猪与藏猪有15个腺苷酸串联,版纳猪有12个。上述结果为进一步研究大猪和小型猪之间生产性能差异的遗传基础提供了新线索。
出处 《猪业科学》 2007年第7期62-64,共3页 Swine Industry Science
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参考文献12

  • 1香猪有黑猪和花猪两个类型——黔东南州第二次香猪品种资源调查[J].中国畜牧杂志,1997,33(6):15-16. 被引量:3
  • 2张仲葛.中国猪品种志[M].上海:上海科学技术出版社,1986..
  • 3Andersen B , Pearse II R V, Jenne K, et al . The Ames dwarf gene is required for Pitl gene activation[J ] . Dev Biol , 1995 , 172 : 495-503.
  • 4Somson M W, Wu W, Dasen J S, et al. Pituitary lineage deter mination by the Prophet of Pit-1 homeodomain factor defec tive in Ames dwarfism. Nature, 1996, 384: 327-333.
  • 5Mody S , Brown M R , Parks J S , et al . The spectrum of hypopituitarism caused by PROP1 mutations[J ] . Best Pract Res Clin Endocrinol Metab , 2002 , 16 (3) : 421-431.
  • 6Osorio M G, Kopp P, Marui S , et al . Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROPI[J ] J Clin Endocrinoi Metab , 2000 , 85 (8) : 2779-2785.
  • 7Sloop KW, McCutchan Schiller A, Smith T P, et al. Biochemical and genetic characterization of the porcine Prophet of Pit1 pituitary transcription factor [J ]. Mol Cell Endocrinol ,2000 , 168 (1 2) : 77-87.
  • 8龚振明,陈鲁勇,方心葵,俞沛初,华修国.梅山猪和香猪Prop-1基因的初步比较[J].中国畜牧杂志,2005,41(11):14-17. 被引量:2
  • 9Fofanova O, Takamura N, Kinoshita E, et al. A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency. Pituitary, 1998, 1: 45-49.
  • 10Wu W, Cogan J D, Pfaffle R W, et al. Mutations in PROP1 cause familial combined pituitary hormone deficiency. Nat Genet, 1998, 18: 147-149.

二级参考文献24

  • 1张志武,于汝梁,王瑞祥,方樟明,郑友民,王雅春.猪产仔数性状基因效应与有效基因数的研究[J].Acta Genetica Sinica,1994,21(4):275-280. 被引量:23
  • 2张仲葛.中国猪品种志[M].上海:上海科学技术出版社,1986..
  • 3Andersen B, Pearse Ⅱ R V, Jenne K, et al. The Ames dwarf gene is required for Pit-1 gene activation[J]. Dev Biol,1995, 172: 495-503.
  • 4Sornson M W, Wu W, Dasen J S, et al. Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism[J]. Nature, 1996, 384 (6607):327-333.
  • 5Mody S, Brown M R, Parks J S, et al. The spectrum of hypopituitarism caused by PROP1 mutations[J]. Best Pract Res Clin Endocrinol Metab, 2002, 16 (3): 421-431.
  • 6Osorio M G, Kopp P, Marui S, et al. Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1[J]. J Clin Endocrinol Metab, 2000, 85 (8): 2779-2785.
  • 7Sloop K W, McCutchan Schiller A, Smith T P, et al. Biochemical and genetic characterization of the porcine Prophet of Pit-1 pituitary transcription factor[J]. Mol Cell Endocrinol,2000, 168 (1-2): 77-87.
  • 8Showalter A D, Smith T P, Bennett G L, et al. Differential conservation of transcriptional domains of mammalian Prophet of Pit-1 proteins revealed by structural studies of the bovine gene and comparative functional analysis of the protein [J].Gene, 2002, 291(1-2): 211-221.
  • 9Eduardo O M, Osvaldo P, de Melo Neto, et al. Adenosinerich elements present in the 5'-untranslated region of PABP mRNA can selectively reduce the abundance and translation of CAT mRNAs in vivo[J]. FEBS Letters, 2003 (546): 329-334.
  • 10Rothschild M,Jacobson C,Vaske D. The estrogen receptor locus is associated with a major gene influencing litter size in pigs. Proc Natl. Acad. Sci. USA,1996,93(1):201~205.

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