110例男性不育患者染色体异常核型临床分析

Clinical Analysis of Chromosomal Abnormality of 110 Cases of Male Patients with Infertility

目的:对110例男性染色体核型进行临床分析,探讨男性染色体畸变与其表型效应的关系。方法:外周血淋巴细胞培养,染色体常规G显带分析。结果:110例男性外周血染色体异常核型中常染色体结构异常占23.6%;性染色体数目异常占70.0%;性染色体结构异常占6.4%。男性染色体异常核型中无精子症占68.2%少精症占2.7%;配偶有反复自发流产、生育死胎、畸胎占29.1%。110例男性染色体异常核型涉及除19、20号染色体外其他染色体。结论:染色体畸变是导致男性不育的重要因素,对久治不愈的不孕不育应检查染色体以排除染色体畸变的可能。

Objective： To study the relationship between chromosome aberrances and their phenotype effect by clinical karyotype analysis of 110 cases of male patients with infertility, Methods： Peripheral blood lymphocyte culture and conventional chromosome analysis by G - band were conducted. Results ： In 110 cases of male patients with chromosome aberrance, abnormal euchromosome structure accounted for 23.6%, The number of sex chromosome abnormalities and abnormal sex chromosome structure accounted for 70.0% and 6.4%, respectively. Among these cases patients with azoospermia and oligospermia were 68.2% and 2.7%, respectively. To their spouses, repeatedly spontaneous abortion, fetal death, terata accounted for 29.1%. Chromosome karyotype abnormalities were showed except the 19th and 20th Chromosome among 110 cases. Conclusion： Chromosome aberrance plays an important role in male infertility. Chromosome examination should be performed to exclude the possibility of chromosome aberrances in patients with obstinate infertility.