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HER2基因阳性乳腺癌的处理 被引量:1

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摘要 Slamon等在1987年通过人乳腺癌的研究,首先报道了原癌基因HER2的扩增,并提示其与肿瘤易复发和预后较差有关。这类肿瘤往往体积较大,患者腋淋巴结常呈阳性,无病生存期较短,对CMF(环磷酰胺、甲氨蝶呤、氟尿嘧啶)化疗可能耐药,对蒽环类药物敏感,其中约50%雌激素受体(ER)阴性。
作者 武正炎
出处 《中华外科杂志》 CAS CSCD 北大核心 2007年第13期889-890,共2页 Chinese Journal of Surgery
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  • 2Agrawal AK,Jelef(n) M,Grzebieniak Z,et al.Androgen receptors as a prognostic and predictive factor in breast cancer.Folia Histochem Cytobiol,2008,46:269-276.
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  • 4Dipen M,Lavinia P,Sijan W,et al.HER-2/neu and p53 overexpression as biomarkers of breast carcinoma in women age 30 years and younger.Cancer,2005,103:900-905.
  • 5Bieche I,Parfait B,Tozlu S,et al.Quantitation of androgen receptor gene expression in sporadic breast tumors by real-time RTPCR:evidence that MYC is an AR-regulated gene.Carcinogenesis,2001,22:1521-1526.
  • 6Park S,KooJ,Park H,et al.Expression of androgen receptors in primary breast cancer.Ann Oncol,2010,21:488-492.
  • 7Diana N,Marius R,Cristian S,et al.Immunohistochemical expression of androgen receptor and prostate-specific antigen in breast cancer.Folia Histochem Cytobio1,2006,44:165-172.
  • 8Luis O,Maria D,Julio V,et al.Androgen receptor expresion in breast cancer:Relationship with clinicopathological characteristics of the tumors,prognosis,and expression of metalloproteases and their inhibitors.BMC Cancer,2008,8:149-159.
  • 9Sφiland H,Kφmer H,Skaland I,et al.Prognostic relevance of androgen receptor detection in operable breast cancer.J Surg Onco1,2008,98:551-558.
  • 10Emad A,Maysa E,Andrew R,et al.Prognostic markers in triplenegative breast cancer.Cancer,2007,109:25-32.

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