淋巴结MR成像中的纳米颗粒对比剂
摘要
淋巴结转移对于癌症分期及预后判断起着至关重要的作用。目前淋巴结成像及良恶性判断仅依赖于大小和形态改变,诊断正确率有限。纳米颗粒MR对比剂以其大小适中、性质独特,结合不同的给药途径可很好地显示淋巴结、淋巴管,准确地进行性质判断。回顾了近年来淋巴结MR成像中纳米颗粒对比剂研究进展,旨在对淋巴结成像的进一步研究有所帮助。
参考文献32
-
1van den Brekel MW. Lymph node metastases: CT and MRI[J]. Eur J Radiol, 2000, 33(3): 230-238.
-
2Alazraki NP, Styblo T, Grant SF, et al. Sentinel node staging of early breast cancer using lymphoscintigraphy and the intraoperative gamma detecting probe [J]. Radiol Clin North Am, 2001, 39 (5): 947-956.
-
3Kobayashi H, Kawamoto S, Choyke PL, et al. Comparison of dendrimer-based macromolecular contrast agents for dynamic micromagnetic resonance lymphangiography[J]. Magn Reson Med, 2003, 50 (4) : 758-766.
-
4Moghimi SM, Bonnemain B. Subcutaneous and intravenous deliver of diagnostic agents to the lymphatic system: applications in lymphoscintigraphy and indirect lymphography [J]. Adv Drug Deliv Rev, 1999, 37(13): 295-312.
-
5Weissleder R, Elizondo G, Wittenberg J, et al. Ultrasmall super- paramagnetic iron oxide: characterization of a new class of contrast agents for MR imaging[J]. Radiology, 1990, 175(2): 489-493.
-
6Rety F, Clement O, Siauve N, et al. MR lymphography using iron oxide nanoparticles in rats: pharmacokinetics in the lymphatic system after intravenous injection[J]. J Magn Reson Imaging, 2000, 12 (5): 734-739.
-
7Misselwitz B. MR contrast agents in lymph node imaging[J]. Eur J Radiol, 2006, 58(3): 375-382.
-
8Trubetskoy VS, Cannillo JA, Milshtein A, et al. Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties[J]. Magn Reson Imaging, 1995, 13(1): 31-37.
-
9Fujimoto Y, Okuhata Y, Tvnqi S, et al. Magnetic resonance lymphography of profundus lymph nodes with liposomal gadolinium- diethylenetriamine pentaacetic acid [J]. Biol Pharm Bull, 2000, 23 (1): 97-100.
-
10Shimada M, Yoshikawa K,Suganuma T, et al. Interstitial magnetic resonance lymphography: comparative animal study of gadofluodne 8 and gadolinium diethylenetriamine-pentaacetic acid [J]. J Comput Assist Tomogr, 2003, 27(4): 641-646.
-
1徐进志,申宝忠.MR淋巴成像研究进展[J].国际医学放射学杂志,2008,31(5):362-366.
-
2陈蓉,龚水根,张伟国,陈金华,何双梧,刘宝华,李增鹏.乳腺癌MRI形态学表现与病理、分子生物学相关性研究[J].中华放射学杂志,2004,38(6):620-625. 被引量:55
-
3蔡宗萍,李伟道.SPECT在肝占位性病变性质判断上的价值[J].重庆医药,1991,20(2):114-115.
-
4张环宇,朱昆生,张安晋,宋元元.二维及彩色多普勒超声对乳腺肿块的诊断价值[J].青海医药杂志,2001,31(12):10-11.
-
5马群.TP方案治疗晚期非小细胞肺癌疗效观察[J].山东医药,2005,45(25):32-32.
-
6李丹,谢珊艳,刘怡安.Ezrin蛋白在宫颈癌中表达及其临床意义[J].中国妇幼保健,2015,30(5):775-777. 被引量:5
-
7杨才胜.局限性肾癌保留肾单位手术45例治疗体会[J].云南医药,2011,32(5):534-535. 被引量:1
-
8范彩霞,陈志喜,赖水招,郑锦坤.羧甲基壳聚糖超小超顺磁氧化铁纳米粒在兔磁共振淋巴成像中的意义[J].实用医学杂志,2013,29(13):2099-2102.
-
9胡安.喉癌手术切缘性质判断[J].临床医药实践,2009,18(3X):176-178. 被引量:1
-
10周箴.骨扫描在术前评估非小细胞肺癌患者分期中的价值[J].诊断学理论与实践,2004,3(3):210-211. 被引量:2