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HLA配型不合/单倍型造血干细胞移植供者淋巴细胞输注量与急性移植物抗宿主病的关系 被引量：2

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摘要 急性移植物抗宿主病（aGVHD）是单倍型造血干细胞移植（HSCT）最常见的并发症之一。其发生率和病死率都较高，而且发病机制非常复杂。T细胞起着核心作用，移植物内T细胞过多可导致GVHD，而去除T细胞或T细胞亚群可以预防GVHD，但移植物被排斥和白血病／淋巴瘤的复发率增多。本研究检测59例HLA配型不合／单倍型HSCT供者淋巴细胞及T细胞亚群数，并分析其与受者aGVHD的关系。
作者 柳金 王卉 陆道培
机构地区 北京大学人民医院血液病研究所
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第7期578-580,共3页 Chinese Journal of Internal Medicine
基金 深圳市科技局2004科技三项经费重点项目(2004081330000008)
关键词 急性移植物抗宿主病 供者淋巴细胞输注 造血干细胞移植 配型不合 单倍型 HLA T细胞亚群 AGVHD
分类号 R55 [医药卫生—血液循环系统疾病]
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参考文献5

二级参考文献40

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共引文献78

同被引文献17

  • 1杨申淼,刘开彦,陆道培.Cobe Spectra与Fenwal CS 3000 Plus血细胞分离器外周血造血干/祖细胞的采集效能比较[J].中国实验血液学杂志,2005,13(2):245-249. 被引量：13
  • 2黄晓军.HLA不合的血缘关系供者异基因造血干细胞移植[J].中华血液学杂志,2006,27(8):575-576. 被引量：7
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  • 5黄河.造血干细胞移植并发症的诊断和治疗,/中华医学会,江苏省医学会.2009年华东地区血液学学术会议暨江苏省第十三次血液学学术会议论文集[G],徐州,2009.南京:江苏省医学会,2009:8-11.
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  • 10Hippen KL, Riley JL, June CH, et al. Clinical perspectives for regulatory T ceils in transplantation tolerance [ J ]. Semin Immunol, 2011,23 ( 6 ) : 462-468. DOI: 10.1016/j.smim.2011.07.008.

引证文献2

二级引证文献7

中华内科杂志
2007年 第7期

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