期刊文献+

重症肌无力患者胸腺组织中SNX17mRNA的表达 被引量:2

原文传递
导出
摘要 重症肌无力(myasthenia gravis,MG)的发病具有一定的遗传倾向性和易患性,与HIA表型、乙酰胆碱受体(AChR)仅亚单位基因、免疫球蛋白重链基因和T细胞受体基因有关。说明MG受多基因调控,揭示MG致病基因类型、结构、突变情况和表达产物等遗传基础对分析MG发病原因十分重要。由于胸腺与MG发病关系密切,我们利用差减杂交文库和基因芯片技术在MG胸腺中筛选出20余个异常表达基因(相关文章待发表),其中分拣微管连接蛋白17(sorting nexins17,SNX17)mRNA表达明显增高。
出处 《中华神经科杂志》 CAS CSCD 北大核心 2007年第7期482-483,共2页 Chinese Journal of Neurology
基金 国家自然科学基金(30570625) 河南省2002年度杰出青年基金(0212000100) 河南省科研院所专项基金(0441130303)
  • 相关文献

参考文献5

  • 1Ciafaloni E, Sanders DB. Advances in myasthenia gravis. Curr Neurol Neurosci Rep, 2002, 2 : 89-95.
  • 2张清勇,杨鲲鹏,苏彦河,张水兰,张斌,尹年太,张灿宇,吉庆春,黄壮士,吕玉珍,黄文玲,孙淑云,兰红,王丽晓.重症肌无力患者围手术期管理[J].郑州大学学报(医学版),2005,40(1):11-13. 被引量:15
  • 3Williams R, Schltlter T, Roberts MS, et al. Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin. Mol Biol Cell, 2004, 15: 3095-3105.
  • 4Stockinger W, Sailler B, Strasser V, et al. The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J, 2002, 21 : 4259-4267.
  • 5Mariathasan S, Bachmann MF, Bouchard D, et al. Degree of TCR internalization and Ca^2+ flux correlates with thymocyte selection. J Immunol, 1998, 161 : 6030-6037.

二级参考文献6

共引文献14

同被引文献19

  • 1许贤豪.重症肌无力研究新展望[J].中华神经科杂志,1997,30(2):67-69. 被引量:9
  • 2Czubayko M, Knauth P, Schliiter T, et al. Sorting nexin 17, a non- self-assembling and a PtdIns (3)P high class affinity protein, inter- acts with the cerebral cavernous mafforttration related protein KRIT1 [J]. Biochem Biophys Res Commun,2006,345(3 ) :1264-1272.
  • 3Steinberg F, Heesom KJ, Bass MD,et al. SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways [J]. J. Cell Biol,2012,197(2) :219-230.
  • 4Donoso M, Caneino J, Lee J, et al. Polarized traffic of I,RPI involves API B and SNXI7 operating on Y-dependent sorting motifs in differ- ent pathways [ J ]. Mol Biol Ce11,2009,20 ( 1 ) : 481-497.
  • 5Marx A, Pfister F, Sehalke B, et al. The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes [J ]. Autoimmun Rev,2013,12(9) :875-84.
  • 6Koneczny I, Cossins J, Vincent A. The role of muscle-specific tyro- sine kinase (MUSK) and mystery of MuSK myasthenia gravis [ J]. J Anat,2014,224( 1 ) :29-35.
  • 7Cui XZ, Ji XY, Gao F,et . Evaluation of the new classification and surgical strategy for myasthenia gravis [ J ]. Am Surg, 2012,78 ( 12 ) : 1329-1335.
  • 8van Weering JR, Cullen PJ. Membrane-associated cargo recycling by tubule-based endosomal sorting [ J ]. Semin Cell Dev Biol, 2014,31 (6) :40-47.
  • 9Ohazama A, Porntaveetus T, Ota MS, et al. Lrp4 : a novel modulator of extracellular signaling in eraniofacial organogenesis [ J ]. Am J Med Genet A,2010,152A(12) :2974-2983.
  • 10FarfOn P, Lee J, Larios J, et al. A sorting nexin 17-binding domain within the LRPI cytoplasmic tail mediates receptor recycling through the basolateral sorting eudosome[ J ]. Traffic ,2013,14 (7) :823-838.

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部