西沙必利、吗叮啉和胃复安治疗功能性消化不良开放性临床对照研究

A STUDY ON THE EFFECTIVENESS IN TREATING FUNCTIONAL DYSPEPSIA BY CISAPRIDE, DOMPERIDONE OR PASPERTIN

我们对48例功能性消化不良的患者用西沙必利进行为期4周的治疗，于第2周及第4周去复诊，西沙必利用量5mgtid饭前15－30分钟服用．并与服用吗叮啉组和胃复安组（各30例）相对照，结果西沙必利组的总有效率高于二对照组，有统计学差异（P＜0．05）．且大部分症状的缓解率优于二对照组．西沙必利、吗叮啉二组的副反应发生率低，相对比无显著差异（P＞0．05），而胃复安组的副反应较多见．

In order to compare the effectiveness of cisapride in treating functional dyspepsia (FD) with that of domperidone and paspertin, 148 cases with FD Were treated by cis apride, 30 ones were treated by domperidone and 30 ones by paspertin. The course of the three groups was four weeks. There was no significant difference among the three groups at the end of two week, after administration but at the end of the coarse the ef fectiveness of cisapride showed better than the other two medicines (P<0.05) The side of fects were fewer in cisapride group and domperidone group than in paspertin group. The conclusion of tbis study is that in treat ing FD cisapridoe bas the more effectiveness and less side effects th an domperidone and paspertin.