1Jemal A,Murray T,Ward E,et al.Cancer statistics[J].CA Cancer J Clin,2005,55:10-30.
2Schiller JH,Harrington D,Belani CP,et al.Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer[J].N Engl J Med,2002,346:92-98.
3Ka men BA,Rubin E,Aisner J,Glatstein E.High-time chemotherapy or high time for low dose[J].J Clin Oncol,2000,18:2935-2937.
4Gasparini G.Metronomic scheduling:the future of chemotherapy[J]? Lancet Oncol,2001,2:733-740.
5Hahnfeldt P,Folkman J,Hlatky L.Minimizing long-term tumor burden:the logic for metronomic chemotherapeutic dosing and its antiangiogenic basis[J].J Ther Biol,2003,220:545-554.
6Stoll BR,Migliorini C,Kadambi A,et al.A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors:implications for anti-angiogenic therapy[J].Blood,2003,102:2555-2561.
7St Croix B,Rago C,Velculoscu V,et al.Genes expressed in human tumor endothelium[J].Science,2000,289:1197-202.
8D'Amore PA,Shima DT.Tumor angiogenesis:a physiological process or genetically determined[J].Cancer Metast Bev,1996,15:205-212.
9Boehm T,Folkman J,Browder T,et al.Anti-angiogenic therapy of experimental cancer does not induce acquired drug resistance[J].Nature,1997,390:404-407.
10Browder T,Butterfield CE,Kr ling BM.et al.Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drugresistant cancer[J].Cancer Res,2000,60:1878-1886.
4Pieter E, Postmus. Activity of pemetrexed (alimta), a new antifolate,against non-small cell lung cancer[J]. Lung Cancer 2002,38(2) : 3-7.
5August G, Alexey M, Mikhail B, et al. A phase Ⅱ study of pemetrexed and carboplatin in patients with locally advanced or metastatic breast cancer[J]. Breast Cancer Res Treat, 2008,110 (2) :309- 315.
6Curtin N, Hughes A. Pemetrexed disodium, a novel antifolate with multiple targets [J]. THE LANCET Oneology, 2001,2 (5):298- 306.
7Bajetta E, Celio L, Buzzoni R, et al. Phase Ⅱ study of pemetrexed disodium (Alimta) administered with oral folie acid in patients with advanced gastric cancer[J]. Ann Oncol, 2003, 14 (10) : 1543-1548.
8Cello L. Muhicenter phase Ⅱ study of pemetrexed and oxaliplatin as first-line therapy in advanced gastric cancer[J]. Journal of Clinical Ontology, 2006,24 (18s) : a14045.
9KimY, Chung H, KangW, et al. Pemetrexed and cisplatin in patients with advanced gastric cancer: a Korean cancer study group multicenter phase Ⅱ study [J]. Cancer Chemother Pharmacol, 2008,62:263-270.
10Stephen C, Michael B, Michael M,et al. A phase Ⅰ/Ⅱ studyof pemetrexed and vinorelbine in patients with non-small cell lung cancer[J]. Lung Cancer, 2005,49(3): 401-412.