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The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4 被引量:12

The magic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4
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摘要 The developmental process from a fertilized egg to a grown adult is programmed with remarkable accuracy. While the genetic information of the fertilized egg and its descendent somatic cells are the same, it is the selective expressions of the same genome that give rise to the 200 or so different cell types in an adult.
出处 《Cell Research》 SCIE CAS CSCD 2007年第7期578-580,共3页 细胞研究(英文版)
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  • 1Wilmut I, Schnieke AE, McWhir J, Kind A J, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature 1997; 385:810-813.
  • 2Gurdon JB. From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Annu Rev Cell Dev Biol 2006; 22:1-22.
  • 3Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-676.
  • 4Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature 2007 6 Jun; doi: 10.1038/nature05934.
  • 5Wemig M, Meissner A, Foreman R, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007 6 Jun; doi: 10.1038/nature05944.
  • 6Maherali N, Sridharan R, Xie W, et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 2007; 1:55-70.

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