Systems perspectives on mRNA processing

到信使 rna 处理的学习的 genomic 技术的申请逐渐地在后生动物的有机体被进行以便理解发生在期间并且在抄写以后的复杂事件。mRNA 蛋白质相互作用和 mRNAdynamics 的大规模系统分析在信使 rna 抄写揭示了特性，拼接，运输，翻译，和周转，并且开始做了在信使 rna 处理的不同的层之间的连接。这里，我们考察 post-transcriptional 过程的全球研究并且讨论在后生动物的有机体面对我们信使 rna 规定的理解的挑战。在平行，我们检验扩展了我们 RNA 有约束力的蛋白质的知识和他们调整的 mRNAsthat 的网络的 genome-scaleinvestigations。

The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after transcription. Large-scale systems analyses ofmRNA-protein interactions and mRNA dynamics have revealed specificity in mRNA transcription, splicing, transport, translation, and turnover, and have begun to make connections between the different layers ofmRNA processing. Here, we review global studies of post-transcriptional processes and discuss the challenges facing our understanding of mRNA regulation in metazoan organisms. In parallel, we examine genome-scale investigations that have expanded our knowledge of RNA-binding proteins and the networks of mRNAs that they regulate.