摘要
在Ｍｏｈａｎｄａｓ工作的基础上，我们采用抗体诱导引起的大白兔球状红细胞贫血病，建立了一种在接近正常生理条件下，同步生长的红细胞衰老的新型动物模型。用此模型，我们连续地监测了从红细胞的新生到红细胞的衰老７０天的红细胞的血球压积、网织细胞计数。结果表明，贫血发生以后，由于应激反应，在注射抗体约１０天内所有的红细胞几乎被新生红细胞所代替。因而，动物体内的红细胞具有类似的年龄特征。由此提示，该红细胞衰老模型是可信的，能够用于研究红细胞的衰老过程并可以观察在衰老过程中与此相关的微观流变特性的改变。
On the basis of Mohandas' work and with the method of using antibody to induce spherocytic anemia of animal, we developed a new animal model, of which red blood cell (RBC) can synchronously grow in a near normal physiological conditions. With this model, we continuously detected the RBC hematocrit, reticulocyte count. The results show that the occurrence of anemia, the process of stimulated RBC proliferation basically finished within 10 days after the injection of antibody, and the RBCs in the body of model animal possess the similar aging characteristics. Therefore, in can be implied that this RBC aging model is reliable, and it is favorable for the study of RBC aging process and the related microrheological changes in the time scale of days.
出处
《中国生物医学工程学报》
CAS
CSCD
北大核心
1997年第2期97-102,共6页
Chinese Journal of Biomedical Engineering
