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激活沉默基因以获取抗生素的发展动态 被引量：2

Progress on New Antibiotic Development by Activation of Silent Genes
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摘要 随着基因工程技术的不断发展和成熟,通过遗传学途径筛选新抗生素和新活性物质的方法不断出现。本文综述了采用基因工程手段激活沉默基因以开发新型抗生素和活性物质的发展动态。较为具体的介绍了两个采用此种方法取得成功的实例,为今后的科研工作提供参考。 With the progress on genetic engineering, many new ways in searching for new antibiotics and other bioactive compounds through genetic modification have been created. In this review, the current progress on identification of the new antibiotics through silent gene activation was elucidated and the successful development of two antibiotics, MM2002 （angucyclines） and notinorhodin using the silent gene activation technique, was discussed in detail.
作者 谢景航 顾觉奋
机构地区 中国药科大学生命科学与技术学院
出处 《国外医药（抗生素分册）》 CAS 2007年第4期178-181,共4页 World Notes on Antibiotics
关键词 沉默基因 激活 基因中断 抗生素 消声器基因 silent gene activation gene disruption antibiotic silencer gene
分类号 R978.1 [医药卫生—药品]
  • 相关文献

参考文献9

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二级参考文献24

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共引文献24

同被引文献40

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国外医药（抗生素分册）
2007年 第4期

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