血浆可溶性纤维蛋白对系统性红斑狼疮患者血栓前状态诊断的意义

The clinical significance of soluble fibrin for diagnosis of prethrombotic state in systemic lupus erythematosus

目的探讨敏感而简单的检测系统性红斑狼疮(SLE)患者血栓前状态的方法。方法测定50例活动期SLE患者血浆可溶性纤维蛋白(sFb),同时检测抗凝血酶Ⅲ(AT-Ⅲ)抗原及活性、D二聚体水平,与50名健康对照者进行比较。结果活动期SLE患者组sFb水平为(1.70±0.23)μg/ml,明显高于对照组的(0.67±0.09)μg/ml(P<0.01)。SLE组AT-Ⅲ抗原及活性(AT-Ⅲ:Ag、AT-Ⅲ:C)低于健康对照组(P<0.01)。SLE组D二聚体的检测结果高于对照组(P<0.01)。结论活动期的SLE患者有血栓形成的倾向。测定患者的sFb水平,连同检测AT-Ⅲ抗原及活性、D二聚体能早期检测患者的血栓前状态。

Objective To explore on a sensitive and simple method to identify the prethrombotie stage in systemic lupus erythematosus （SEE）. Methods The levels of soluble fibrin （sFb）, antithrombin Ⅲ antigen （AT-Ⅲ -Ag）, antithrombin Ⅲ C （AT-Ⅲ ：C） and D-dimmer （D-D） were measured in 50 cases of active SLE and 50 cases of healthy controls. Results The level of sFb in SLE group was （1.70±0.23）μg/ml vs （0.67±0.09）μg/ml in the control group （P〈0.01）. The levels of AT-Ⅲ：Ag, AT-Ⅲ：C in the SLE group were lower than those in the control group （P〈0.01）. Higher level of D-D was also found in the SLE group as compared with the control group （P〈0.01）. Conclusion The results of this study suggested that patients with active SLE were susceptible to thrombosis. Measurement of sFb and AT-ⅢAg, AT-Ⅲ：C and D-D may be helpful for early diagnosis of prethrombotic stage in SLE patients.