七方胃痛散联合奥美拉唑对胃溃疡患者胃黏膜形态学的影响

Morphological Observation on Gastric Mucosa Membrane of Patients with Gastric Ulcer Treated with Combined Use of Qifang Weitong Powder and Omeprazole

目的观察七方胃痛散联合奥美拉唑片治疗活动性胃溃疡患者前后胃黏膜组织学变化。方法60例患者随机分为两组,第1周治疗时两组均予根除幽门螺杆菌三联疗法,第2～8周时治疗组(30例)给予七方胃痛散联合奥美拉唑片治疗,对照组(30例)仅用奥美拉唑片治疗。治疗结束后,胃镜下取患者胃溃疡周围黏膜进行组织学观察。结果治疗后两组胃镜疗效相似;治疗组胃黏膜厚度和腺体形态改善程度优于对照组(P<0.05)。结论七方胃痛散能恢复活动性胃溃疡患者的胃黏膜形态结构,增强溃疡愈合的组织学质量。

Objective To observe the histological changes of gastric mucosa in patients with active gastric ulcer before and after treatment by Qifang Weitong Powder combined with Omeprazole （QWP-Op）. Methods Sixty patients were equally randomized into the treated group and the control group. They were all treated in the 1st week by the Helicobacter pylori eradication triad regimen. From the 2nd to 6th week, the study group received QWP-Op therapy, and the control group was given Omeprazole alone. Biopsy specimens were obtained around ulcer area before and after treatment for histological observation on changes of gastric mucosa membrane. Results The improvement of mucosal thickness and glandular morphology was better in the treated group than that in the control group （P 〈 0.05）. Conclusion QWP-Op therapy can improve the histological quality of ulcer healing and restore the morphological structure of gastric mucosa in patients with active gastric ulcer.