摘要
目的探索中药复方别敏对变应性鼻炎干预作用机制。方法采用卵清蛋白(OVA)腹腔注射造成变应性鼻炎小鼠模型,观察小鼠行为学变化、脾脏淋巴细胞增殖能力及血清总IgE和OVA特异性IgE含量的变化。结果中药复方别敏能明显减少变应性鼻炎模型小鼠的抓鼻和喷嚏数;抑制植物血凝素A和OVA刺激引起的脾脏淋巴细胞增殖;降低血清总IgE和OVA特异性IgE含量。结论中药复方别敏具有抑制脾脏淋巴细胞增殖,降低血清IgE等作用。
Objective To investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis (AR). Methods AR model of mouse was induced by intraperitoneal injection of ovalbumin (OVA), and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed. Results Biminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phytohemagglutinin (PHA) and OVA, and lowering the levels of serum total IgE and OVA specific IgE. Conclusion Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2007年第7期623-625,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
上海市科委科研攻关项目(No.02DZ19128).
关键词
中药复方别敏
变应性鼻炎
淋巴细胞增殖
免疫球蛋白E
Chinese compound Biminne
allergic rhinitis
lymphocyte proliferation
immunoglobulin E