中药复方别敏治疗变应性鼻炎的实验研究

Study on Mechanism of Biminne in Treating Allergic Rhinitis

目的探索中药复方别敏对变应性鼻炎干预作用机制。方法采用卵清蛋白(OVA)腹腔注射造成变应性鼻炎小鼠模型,观察小鼠行为学变化、脾脏淋巴细胞增殖能力及血清总IgE和OVA特异性IgE含量的变化。结果中药复方别敏能明显减少变应性鼻炎模型小鼠的抓鼻和喷嚏数;抑制植物血凝素A和OVA刺激引起的脾脏淋巴细胞增殖;降低血清总IgE和OVA特异性IgE含量。结论中药复方别敏具有抑制脾脏淋巴细胞增殖,降低血清IgE等作用。

Objective To investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis （AR）. Methods AR model of mouse was induced by intraperitoneal injection of ovalbumin （OVA）, and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed. Results Biminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phytohemagglutinin （PHA） and OVA, and lowering the levels of serum total IgE and OVA specific IgE. Conclusion Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.