一种新型人TNFα对人肝癌裸鼠移植瘤的抗瘤作用

ANTI TUMOR EFFECTS OF A NEW rhTNFα ON HUMAN LIVER CANCER IMPLANTED IN NUDE MICE

用人肝癌Ｂｅｌ７４０２瘤株建立了人肝癌裸鼠移植瘤模型，探讨新型重组人ＴＮＦα（ｒｈＴＮＦαＤ１１ａ）对这种移植瘤的抗瘤作用。结果表明，ｒｈＴＮＦαＤ１１ａ和原型重组人ＴＮＦα（ｒｈＴＮＦα）的抑瘤率在３０％左右时，后者所用的活性单位数是前者的２倍；两者用量相同时，前者的抑瘤率比后者提高２３个百分点。

In order to investigate the effects of rhTNFα D11a on the experimental human cancer, a human liver cancer implant model was established by using nude mice and a liver cancer strain——Bel 7402. It was showed that when the tumor inhibition rates of both rhTNFα D11a and rhTNFα reached about 30%, the activity unit needed by the latter was as two time as that by the former.The tumor inhibition rate of the fomer was as 1.74 times as that of the latter when injected with same doses.