钙拮抗剂尼莫地平救治重型颅脑损伤的临床研究

THE CLINIC STUDY ON THE TREATMENT OF SEVERE CRANIOCEREBRAL TRAUMA WITH NIMODIPINE

观察了钙拮抗剂尼莫地平对重型颅脑损伤的治疗作用。尼莫地平治疗组３４６例，常规治疗对照组１４２例，结果表明，尼莫地平治疗组颅内压升高幅度较小，ＣＴ动态扫描脑水肿明显减轻，临床恢复良好率达８０．１％，病死率明显下降，仅为１８．２％。并就尼莫地平救治重型颅脑损伤的作用及有关机制等进行了讨论。

The authors report the effcts of a calcium antagonist, nimodipine,on severe craniocerebral trauma. A total of 488 cases of severe craniocerebral trauma with Glasgow Coma Scale(GCS) 3～8 score were recruited into the clinical study. The patients were divided into two groups:(1) therapeutic group (346 cases),teated with nimodipine; (2) control group (142 cases), with conventional drugs,such as mannitol, diuretics and hemostatics. CT scanning showed that in the patients treated with nimodipine, the increase of intracranial pressure was not very remarkable, and the brain edema alleviated markedly. The rate of good recovery was as high as 80 1%, and the case fatality rate decreased to 18 2% in the therapeutic group. The mechanism and effect of nimodipine on the severe craniocerebral trauma were discussed.