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库普弗细胞与肝纤维化的关系 被引量：2

Kupffer cells and liver fibrosis
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摘要 活化的库普弗细胞发挥吞噬、抗原提呈、释放细胞因子、免疫调节等功能，成为机体防御的重要屏障，同时也参与了肝脏的炎症损伤、纤维化的形成和降解等病理过程。
作者 李丽 王宝恩
机构地区 首都医科大学附属北京友谊医院肝病中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2007年第7期559-560,共2页 Chinese Journal of Hepatology
关键词 肝硬化 肝纤维化 库普弗细胞 Liver cirrhosis Liver fibrosis Kupffer cell
分类号 R686 [医药卫生—骨科学]
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参考文献15

  • 1Schebesch C, Kodelja V, Muller C, et al. Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4+ T cells in vitro. Immunology, 1997, 92: 478- 486.
  • 2Muriel P, Escobar Y. Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride. J Appl Toxicol, 2003, 23: 103-108.
  • 3Giakoustidis DE, Iliadis S, Tsantilas D, et al. Blockade of Kupffer cells by gadolinium chloride reduces lipid peroxidation and protects liver from ischemia/reperfusion injury. Hepatogastroenterology, 2003, 50: 1587-1592.
  • 4Wang H, Wei W, Wang NP, et al. Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress. Life Sci, 2005, 77: 1902-1915.
  • 5Leonarduzzi G, Scavazza A, Biasi F, et al. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor betal expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. FASEB J, 1997, 11: 851-857.
  • 6Tomita K, Tamiya G, Ando S, et al. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice.Gut, 2006, 55: 415-424.
  • 7Hironaka K, Sakaida I, Matsumura Y, et al. Enhanced interstitial collagenase (matrix metaUoproteinase- 13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis. Biochem Biophys Res Commun, 2000, 267: 290-295.
  • 8Xidakis C, Ljumovic D, Manousou P, et al. Production of pro- and anti-fibrotic agents by rat Kupffer cells; the effect of octreotide.Dig Dis Sci, 2005, 50: 935-941.
  • 9Fischer R, Cariers A, Reinehr R, et al. Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells. Gastroenterology, 2002, 123: 845-861.
  • 10Xaus J, Comalada M, Valledor AF, et al. LPS induces apoptosis in macrophages mostly through the autocrine production of TNF-alpha. Blood, 2000, 95: 3823-3831.

同被引文献8

  • 1慢性乙型肝炎防治指南[J].中华传染病杂志,2005,23(6):421-431. 被引量：824
  • 2FRIEDMAN SL, BANSAL MB. Reversal of hepatic fibrosis-fact or fantasy[ J]. Hepatology,2006,43 (2 Suppl 1) :82.
  • 3FRIEDMAN SL, ROCKEY DC, BISSELL DM. Hepatic fibrosis2006 : rePort of the Third AASLD Single TOPie Conference[ J]. Hepatology, 2007,45:242.
  • 4TORI AM,EDDIE L, GREENE M. Aldosterone induces the increase of ACE mRNA in rats glomerular mesangial cells [ J ]. J Am Soc Nephrol.1998.9:77.
  • 5TANAKA J, FUJITA H, MATSUDE S. Glucocorticoid and mineralocorticoid receptors in microglial cells[J]. Cire Res,2000,71:503.
  • 6Bautista A P.Chronic alcohol intoxication primes Kupffer cells and endothelial cells for enhanced CC-chemokine production and concomitantly suppresses phagocytosis and chemotaxis. Frontiers in Bioscience . 2002
  • 7Bautista A P.Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology . 1997
  • 8董波,黄定九,李慧丽,向祖琼.血管紧张素II对单核细胞趋化因子及粘附分子表达的影响[J].上海免疫学杂志,2002,22(2):104-106. 被引量：19

引证文献2

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中华肝脏病杂志
2007年 第7期

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