加替沙星治疗女性非淋菌性泌尿生殖道炎的临床观察

Clinical observation of gatifloxacin in treatment of female nongorcoccal urethritis and genital tract infection

目的探讨加替沙星治疗女性非淋菌性泌尿生殖道炎的有效性和安全性。方法采用对照研究,试验组48例,服用加替沙星0.2 g,po,bid,连续服用1 wk;对照组48例,服用左氧氟沙星0.2 g,po,bid,连续服用1 wk。结果2组痊愈、有效、无效病例分别为46、20、和28、12、8例,经Ridit分析差异有统计学意义(P<0.05);不良反应发生率分别为16.7%和22.9%,差异无统计学意义(P>0.05)。结论加替沙星治疗女性非淋菌性生殖道炎安全有效。

AIM To study the efficacy and safety of gatifloxacin in treatment of female nongorcoccal urethritis and genital tract infection. METHODS A randomized and parallel control clinical trial was conducted. The treatment group （n =48） was treated with gatifloxacin, 0.2 g,po ,bid,for 7 d.The control group （n = 48） was treated with levoflxacin 0.2 g,po ,bid,for 7 d. RESULTS The cure rate,effective rate and ineffective rate for 2 groups were 95.8% ,4.2% ,0 and 58.3% ,25%, 16.7%, respectively. A significant difference existed between 2 groups （ P 〈 0.05）. The occurring rate of adverse drug reactions was 16.7 % and 22.9%, respectively. CONCLUSION Gatifioxacin is effective and safe in the treatment of female nongorcoccal urethritis and genital tract infection.