变形链球菌菌斑生物膜相关基因突变的研究进展

Development of study on gene mutation related to dental plaque biofilm of Streptococcus mutans

变形链球菌能生成菌斑生物膜,后者与龋病的发生密切相关。随着现代口腔医学和分子生物学的发展,菌斑生物膜相关基因的研究也越来越多,发现了许多与之相关的基因,主要包括与黏附力相关的基因、与群体感应信号系统相关的基因等。对变形链球菌菌斑生物膜相关基因的研究可以更深入地了解其致龋机制,并对寻找防龋新途径作出有益的探索。本文就近年来与变形链球菌菌斑生物膜相关的基因突变研究作一综述。

Streptococcus mutans （S. mutans） can produce dental plaque biofilm, which is closely related to dental caries. With the development of modern stomatology and molecular biology, there are more and more studies on genes related to dental plaque biofilm. As a result, lots of the genes are found, mainly including those involved in adhesion, quorum-sensing signal system and so on. Studying these genes can further ensure the mechanisms about formation of dental caries, and has also explored new way to prevent dental caries. In this article, the studies on gene mutation related to dental plaque biofilm of S. mutans in recent years have been reviewed.