一步法合成4-(反式-4′-正戊基环己基)环己酮

Synthesis of 4-(4′-trans-n-pentyicyclohexyl)cyclohexanone by One-step Hydrogenation

以较少量(质量分数4%)的国产商品化钯/炭为催化剂,在温度160℃,压力0.60～0.70 MPa条件下,由4-(反式-4′-正戊基环己基)苯酚加氢合成了4-(反式-4′-正戊基环己基)环己酮,酚的转化率为97.1%,酮的选择性为85.5%,加以高锰酸钾氧化进行后处理,少量原料酚可直接氧化去除,醇则氧化为目标酮,总收率85.2%。该反应体系催化剂用量较少,且安全与环保。

4- （4′-trans-n-pentylcyc lohexyl ） cyclohe xanone was prepared from 4- （ 4′-trans-n-pentylcyclohe xyl ） phenol by one-step hydrogenation using Pd/C as catalyst, the optimal reaction condition is the combination of 4 %（mass fraction） Pd/C, 160℃ reaction temperature and 0.6~0.7 MPa pressure. The conversion of 4-（4′-trans-n-pentylcyclohexyl）phenol was 97.1 %, the selectivity of 4-（4＇-trans-n-pen- tyleyelohexyl）eyelohexanone was 85.5 %, KMnO4 was used to converse the side product alcohol to cyclohexanone and dispose the starting material after reaction, the total yield was 85. 2 %. This method is economic and environmental friendly, can be applied in industry.