摘要
载脂蛋白E(apolipoprotein E,APOE)基因在阿尔茨海默病(Alzheimer disease,AD)的研究中起着重要作用,已经明确APOE基因与老年性痴呆病关系密切。近年来,人们利用分子生物学技术对普通人群及患者APOE基因多态性与AD的关系进行了广泛的研究。笔者就此领域的研究进展做一综述,以期为AD相关研究提供基础信息。
The Apolipoprotein E （APOE）gene plays important roles in the pathogenesis of the Alzheimer disease （AD）. It is clear that APOE gene is closely related with dementia in the elderly. In recent years, extensive researches regarding the relationship between APOE gene polymorphism and AD has been conducted in both health population and patients with AD using molecular biology technique. This paper reviewed the progress in this field for sharing some fundamental information on the research in AD
出处
《基础医学与临床》
CSCD
北大核心
2007年第7期739-744,共6页
Basic and Clinical Medicine
